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Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods
08:28

Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods

Published on: March 10, 2020

Prevalence of congenital cardiovascular malformations varies by race and ethnicity

Tania Mangones1, Amitoz Manhas, Paul Visintainer

  • 1Division of Newborn Medicine, Department of Pediatrics, Maimonides Infants and Children's Hospital of Brooklyn, United States.

International Journal of Cardiology
|April 7, 2009
PubMed

Insights

Congenital cardiovascular malformations (CCVMs) are most prevalent in Non-Hispanic White populations in New York State's Hudson Valley Region. Hispanics showed a consistently lower risk for most CCVMs, indicating racial disparities in these common birth defects.

Area of Science:

  • Cardiology
  • Pediatrics
  • Public Health

Background:

  • Congenital cardiovascular malformations (CCVMs) are leading causes of infant morbidity and mortality.
  • Limited data exists on the association between CCVMs and race/ethnicity.
  • This study addresses CCVM prevalence by race in New York State's Hudson Valley Region (HVR).

Purpose of the Study:

  • To determine the prevalence of CCVMs across different racial and ethnic groups in the HVR.
  • To identify potential disparities in CCVM occurrence based on race and ethnicity.

Main Methods:

  • Utilized data from the NYS Department of Health Congenital Malformations Registry (1992-2001).
  • Analyzed live-birth cases diagnosed up to 2 years of age.
  • Calculated prevalence using race/ethnic-specific births and employed Poisson regression models.

Main Results:

  • Overall CCVM prevalence was highest in Non-Hispanic White (14.4/1000) and lowest in Hispanic (8.8/1000) populations.
  • Hispanics exhibited a lower risk for most CCVMs compared to Non-Hispanic Whites.
  • Minimal temporal and regional variations in prevalence were observed.

Conclusions:

  • Non-Hispanic White individuals in the HVR have the highest prevalence of CCVMs.
  • Hispanic populations consistently demonstrate a lower risk for CCVMs and specific related anomalies.
  • Findings highlight racial and ethnic disparities in congenital cardiovascular malformations.
Abstract

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