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Updated: Jul 14, 2026
11:17
Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor
Published on: February 10, 2014
Summary
Cimetidine, a histamine H2-receptor antagonist, did not alter sodium gain or acid loss in dog stomach pouches. It also failed to protect the stomach lining from bile salt damage.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Histamine H2-receptor antagonists are used to reduce stomach acid.
- The role of cimetidine in protecting the gastric mucosal barrier is not fully understood.
Purpose of the Study:
- To investigate the effect of cimetidine on gastric mucosal barrier function in dogs.
Main Methods:
- Vagally-denervated pouches of antrectomised dogs were used.
- Cimetidine was administered topically and parenterally.
- Net luminal Na+ gain and H+ loss were measured.
- The effect of sodium taurocholate on mucosal barrier disruption was assessed with and without cimetidine.
Main Results:
- Cimetidine did not affect net luminal Na+ gain or net luminal H+ loss.
- Cimetidine did not prevent mucosal barrier disruption caused by sodium taurocholate.
Conclusions:
- Cimetidine does not appear to protect the gastric mucosal barrier against acid loss or bile salt-induced damage in this canine model.
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