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Outcome and extent of disability following Japanese encephalitis in Indonesian children

Masri Sembiring Maha1, Vanda A Moniaga, Susan L Hills

  • 1National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|April 7, 2009
PubMed

Insights

Japanese encephalitis (JE) in Indonesian children often results in death or severe disability, impacting independence. Immunization is crucial to prevent JE and reduce its societal and economic burden.

Area of Science:

  • Pediatric infectious diseases
  • Neurology
  • Public health

Background:

  • Japanese encephalitis (JE) poses a significant health threat to children in endemic regions.
  • Understanding the long-term outcomes of JE is crucial for developing effective interventions.

Purpose of the Study:

  • To evaluate the outcomes and disability levels in Indonesian children following Japanese encephalitis.
  • To assess the long-term impact of JE on children's ability to live independently.

Main Methods:

  • A cohort of 72 laboratory-confirmed JE cases in children was followed.
  • Disability was assessed using the Liverpool Outcome Score at least 4 months post-hospital discharge.

Main Results:

  • Outcome data was available for 65 children (90%).
  • 25% of children died, and 25% experienced severe sequelae, likely leading to dependency.
  • An additional 25% had moderate or minor sequelae, with only 25% fully recovering.

Conclusions:

  • Half of the children with JE either died or suffered severe disabilities, highlighting the disease's profound impact.
  • JE immunization programs are recommended to prevent cases and mitigate the economic and social burden in Indonesia.
Abstract

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