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Related Experiment Video

Updated: Jun 24, 2026

In vivo Imaging of Transgenic Leishmania Parasites in a Live Host
09:53

In vivo Imaging of Transgenic Leishmania Parasites in a Live Host

Published on: July 27, 2010

Imaging schistosomes in vivo.

Greice Krautz-Peterson1, David Ndegwa, Kristine Vasquez

  • 1Department of Biomedical Sciences, Tufts University, Cummings School of Veterinary Medicine, 200 Westboro Rd., North Grafton, MA 01536, USA.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|April 7, 2009
PubMed
Summary

Novel imaging visualizes live schistosomes (parasitic worms) within hosts. This breakthrough aids in developing new treatments for schistosomiasis, a major global disease.

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Area of Science:

  • Parasitology
  • Medical Imaging
  • Drug Discovery

Background:

  • Schistosomiasis affects over 200 million people globally.
  • Current methods for studying schistosomes in vivo are limited.
  • Understanding schistosome biology is crucial for treatment development.

Purpose of the Study:

  • To develop and validate novel imaging techniques for live schistosomes.
  • To enable real-time visualization of schistosomes within their hosts.
  • To facilitate the discovery of new schistosomiasis therapies.

Main Methods:

  • Utilized a fluorescent agent for parasite gut uptake and activation.
  • Employed fluorescence molecular tomography (FMT) for detection and quantitation.
  • Applied imaging to track parasite reduction in praziquantel-treated mice.

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Cercarial Transformation and in vitro Cultivation of Schistosoma mansoni Schistosomules
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Cercarial Transformation and in vitro Cultivation of Schistosoma mansoni Schistosomules

Published on: August 16, 2011

Intravital Microscopy of the Spleen: Quantitative Analysis of Parasite Mobility and Blood Flow
11:36

Intravital Microscopy of the Spleen: Quantitative Analysis of Parasite Mobility and Blood Flow

Published on: January 14, 2012

Related Experiment Videos

Last Updated: Jun 24, 2026

In vivo Imaging of Transgenic Leishmania Parasites in a Live Host
09:53

In vivo Imaging of Transgenic Leishmania Parasites in a Live Host

Published on: July 27, 2010

Cercarial Transformation and in vitro Cultivation of Schistosoma mansoni Schistosomules
05:30

Cercarial Transformation and in vitro Cultivation of Schistosoma mansoni Schistosomules

Published on: August 16, 2011

Intravital Microscopy of the Spleen: Quantitative Analysis of Parasite Mobility and Blood Flow
11:36

Intravital Microscopy of the Spleen: Quantitative Analysis of Parasite Mobility and Blood Flow

Published on: January 14, 2012

Main Results:

  • Successfully visualized live schistosomes within hosts using fluorescence.
  • Demonstrated a strong positive correlation between fluorescence signal and parasite number.
  • Observed gut fluorescence in Schistosoma mansoni, S. japonicum, and S. hematobium.

Conclusions:

  • Novel imaging technology allows unprecedented visualization of schistosomes.
  • This method can accelerate the identification of new antischistosome drugs.
  • Provides direct visual insight into the intravascular lifecycle of human schistosomes.