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Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice

Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice

Published on: February 18, 2015

Cardiac mucormycosis with T-cell immunodeficiency.

S Shah¹, P V Suresh, S Maheshwari

¹Department of Pediatric Cardiology, Narayana Hrudayalaya, Bangalore, India. sejalshahsuresh@yahoo.com

Indian Pediatrics

|April 7, 2009

Summary

A pediatric mucormycosis case presented with a mitral valve mass and fever. Recurrence with central nervous system (CNS) embolization revealed an underlying T-cell immunodeficiency.

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Published on: August 1, 2014

Area of Science:

Pediatric Cardiology
Infectious Diseases
Immunology

Background:

Mucormycosis is a rare but severe fungal infection, particularly in immunocompromised individuals.
Cardiac involvement in pediatric mucormycosis is exceptionally uncommon.
Early diagnosis and management are crucial for patient outcomes.

Observation:

A 2-year-old child presented with fever and an unusual mitral valve mass.
Surgical excision and histopathology confirmed the mass as mucormycosis.
Four months later, the child experienced central nervous system (CNS) embolization and cardiac lesion recurrence.

Findings:

Histopathological analysis confirmed mucormycosis as the cause of the cardiac mass.
Further investigations identified an associated T-cell immunodeficiency.
The recurrence and CNS involvement highlight the aggressive nature of the infection in this context.

Implications:

This case underscores the importance of considering mucormycosis in pediatric cardiac masses, especially with atypical presentations.
Identifying underlying immunodeficiencies, such as T-cell defects, is critical for managing recurrent fungal infections.
This highlights the need for comprehensive diagnostic workups in pediatric patients with severe fungal infections and recurrent disease.