Related Experiment Video
Updated: Jun 24, 2026
12:17
The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
Published on: August 2, 2017
Placental growth factor: a predictive marker for preeclampsia?
Markus Schmidt1, Canan Dogan, Cahit Birdir
1Department of Gynecology and Obstetrics, University of Duisburg-Essen, Essen, Germany. markus.schmidt@uk-essen.de
Gynakologisch-Geburtshilfliche Rundschau
|April 7, 2009
Summary
Low placental growth factor (PLGF) levels in early pregnancy may predict preeclampsia. Measuring PLGF between 15-18 weeks can identify women at higher risk for developing this condition.
Area of Science:
- Obstetrics and Gynecology
- Maternal-Fetal Medicine
- Reproductive Biology
Background:
- Preeclampsia pathogenesis involves an imbalance of angiogenic and antiangiogenic factors.
- Serum placental growth factor (PLGF) levels are notably lower in preeclamptic pregnancies.
- Investigating PLGF as an early predictive marker for preeclampsia is crucial.
Purpose of the Study:
- To determine if PLGF measurement in the second trimester can predict preeclampsia.
- To assess the diagnostic accuracy of PLGF for preeclampsia prediction.
Main Methods:
- Serum samples collected from 61 women between 15-18 weeks gestation.
- Human PLGF ELISA used to quantify serum PLGF levels.
- Correlation of PLGF levels with pregnancy outcomes.
Main Results:
- Preeclampsia developed in 7 women (11.47%).
- Significantly lower PLGF levels (p < 0.001) were observed in women who developed preeclampsia.
- A PLGF cutoff of 41.84 pg/ml demonstrated 87% sensitivity and 83% specificity.
Conclusions:
- Reduced PLGF expression in early pregnancy is associated with later preeclampsia development.
- PLGF measurement offers a promising tool for early preeclampsia prediction.
- This biomarker aids in identifying pregnancies at risk for preeclampsia.
