Veterans' attitudes regarding a database for genomic research

Area of Science:

• Genomic research
• Population health studies
• Bioinformatics

Background:

• Large cohort studies investigating gene-environment-lifestyle interactions necessitate representative population samples.
• The Department of Veterans Affairs (VA) healthcare system, with its extensive patient base and electronic health records, is well-suited for such research.
• Establishing a large-scale genetic and medical records database within the VA is under consideration for research purposes.

Purpose of the Study:

• To assess the willingness of Veterans Affairs patients to participate in a proposed genomic research database.
• To identify patient concerns regarding participation in a genomic study.
• To understand patient preferences for study design components.

Main Methods:

• An online survey was administered to 931 Veterans Affairs patients in April-May 2008.
• Respondents were informed about a proposed genomic study and surveyed on their support, willingness to participate, and opinions on study aspects.
• Descriptive analysis explored demographic differences in attitudes and the association between general beliefs and study support/participation.

Main Results:

• 83% of respondents supported the creation of the genomic database.
• 71% of respondents indicated they would definitely or probably participate in the study.
• Support and willingness to participate were observed across a broad range of demographic groups.

Conclusions:

• The majority of Veterans Affairs health patients across diverse demographics support establishing a genomic database and are willing to participate.
• A strong desire to learn about personal health was a key motivator for participation.
• Altruistic motivations were significantly correlated with veterans' willingness to participate in the genomic study.