Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

6.6K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Autoimmunity and <i>H. pylori</i> infection cooperatively promote epithelial tumorigenic differentiation and systemic immune modulation.

bioRxiv : the preprint server for biology·2025
Same author

Mechanistic Insights into Hybridization-Based Off-Target Activity of GalNAc-siRNA Conjugates.

Nucleic acid therapeutics·2025
Same author

Toxicologic Neuropathology of Novel Biotherapeutics.

Toxicologic pathology·2024
Same author

The lncRNA HOXA11os regulates mitochondrial function in myeloid cells to maintain intestinal homeostasis.

Cell metabolism·2023
Same author

Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates.

Nature biotechnology·2022
Same author

Alterations of epigenetic regulators and P53 mutations in murine mesenchymal stem cell cultures: A possible mechanism of spontaneous transformation.

Cancer biomarkers : section A of Disease markers·2021

Related Experiment Video

Updated: Feb 16, 2026

Mouse Models Of Helicobacter Infection And Gastric Pathologies
07:43

Mouse Models Of Helicobacter Infection And Gastric Pathologies

Published on: October 18, 2018

22.6K

Helicobacter-based mouse models of digestive system carcinogenesis.

Arlin B Rogers1, JeanMarie Houghton

  • 1Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA.

Methods in Molecular Biology (Clifton, N.J.)
|April 7, 2009
PubMed
Summary

Mouse models are crucial for studying infectious carcinogenesis in the digestive system, validating Helicobacter pylori

Area of Science:

  • Gastroenterology and Hepatology
  • Oncology
  • Microbiology and Immunology

Background:

  • Infectious carcinogenesis of the digestive system requires complex animal models reflecting host, microbial, and environmental factors.
  • Mouse models are preferred due to cost, speed, reagent availability, and genetic manipulability for studying gene functions in vivo.
  • Previous research has validated Helicobacter pylori as a risk factor for gastric carcinoma and Enterohepatic Helicobacter spp. in inflammatory bowel disease and colorectal carcinoma.

Purpose of the Study:

  • To summarize important mouse models of inflammation-associated cancer incited by murine Helicobacter infection.
  • To describe methods for collecting, sampling, and histologically grading mouse digestive system tissues.
  • To explore mechanisms of inflammation-associated liver cancer using Helicobacter hepaticus models.

More Related Videos

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
06:01

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

Published on: July 6, 2017

10.0K
Surgical Models of Gastroesophageal Reflux with Mice
05:19

Surgical Models of Gastroesophageal Reflux with Mice

Published on: August 25, 2015

10.8K

Related Experiment Videos

Last Updated: Feb 16, 2026

Mouse Models Of Helicobacter Infection And Gastric Pathologies
07:43

Mouse Models Of Helicobacter Infection And Gastric Pathologies

Published on: October 18, 2018

22.6K
A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
06:01

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

Published on: July 6, 2017

10.0K
Surgical Models of Gastroesophageal Reflux with Mice
05:19

Surgical Models of Gastroesophageal Reflux with Mice

Published on: August 25, 2015

10.8K

Main Methods:

  • Utilizing genetically engineered mouse models to study specific gene functions in vivo.
  • Employing Helicobacter-based mouse models to investigate inflammation-associated digestive system cancers.
  • Describing tissue collection, sampling, and histologic grading techniques for mouse digestive system tissues.

Main Results:

  • Mouse models have confirmed Helicobacter pylori as a major risk factor for gastric carcinoma.
  • Enterohepatic Helicobacter spp. models allow study of host immunity and microbial factors in inflammatory bowel disease and colorectal carcinoma.
  • The Helicobacter hepaticus model identified a potential mechanism for male-predominant liver cancer risk independent of sex hormones.

Conclusions:

  • Helicobacter-based mouse models are essential for investigating the basic biology of inflammation-associated human cancers.
  • These models are valuable for evaluating therapeutic interventions at the discovery level.
  • Advances in genetic engineering, in vivo imaging, and omics technologies will enhance the utility of these models for future research.