Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Spongy Bone01:09

Spongy Bone

All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Treatment concepts for complications after resection and defect reconstruction of pelvic tumours].

Der Orthopade·2020
Same author

[Endoprostheses for stump formation after hip disarticulation].

Der Orthopade·2019
Same author

Der Orthopade·2017
Same author

Acetabular and pelvic fractures in multiple trauma.

Der Orthopade·2017
Same author

Treatment of Pipkin fractures.

Der Orthopade·2017
Same author

Secondary operation for elbow flexion reconstruction after brachial plexus lesion.

Der Orthopade·2017
Same journal

[3D printing in fracture treatment : Current practice and best practice consensus].

Der Unfallchirurg·2022
Same journal

[3D printing in trauma surgery : Germany lags far behind].

Der Unfallchirurg·2022
Same journal

[Subtrochanteric fractures].

Der Unfallchirurg·2022
Same journal

[3D printing in the field of shoulder surgery].

Der Unfallchirurg·2022
Same journal

[New assessment recommendations for disability in private accident insurance, part 1 : An interdisciplinary consented approach-Basics].

Der Unfallchirurg·2022
Same journal

[Amputation techniques].

Der Unfallchirurg·2022
See all related articles

Related Experiment Video

Updated: Jun 24, 2026

Surgical Angiogenesis in Porcine Tibial Allotransplantation: A New Large Animal Bone Vascularized Composite Allotransplantation Model
10:31

Surgical Angiogenesis in Porcine Tibial Allotransplantation: A New Large Animal Bone Vascularized Composite Allotransplantation Model

Published on: August 13, 2017

[Vascularized bone transfer].

R Hierner1, G Täger, D Nast-Kolb

  • 1Plastische, Rekonstruktive, Asthetishe und Handchirurgie, Zentrum für Interdisziplinäre Rekonstruktive Chirurgie, Universitätsklinikum Essen der Universität Duisburg-Essen, Hufelandstrasse 55, Essen, Germany. robert.hierner@uk-essen.de

Der Unfallchirurg
|April 7, 2009
PubMed
Summary
This summary is machine-generated.

Vascularized bone grafts, with their own blood supply, offer superior fracture healing and survival rates, especially in challenging conditions. This makes them effective for treating large bone defects with fewer complications.

More Related Videos

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts
13:16

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts

Published on: December 22, 2015

Use of Human Perivascular Stem Cells for Bone Regeneration
07:05

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

Related Experiment Videos

Last Updated: Jun 24, 2026

Surgical Angiogenesis in Porcine Tibial Allotransplantation: A New Large Animal Bone Vascularized Composite Allotransplantation Model
10:31

Surgical Angiogenesis in Porcine Tibial Allotransplantation: A New Large Animal Bone Vascularized Composite Allotransplantation Model

Published on: August 13, 2017

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts
13:16

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts

Published on: December 22, 2015

Use of Human Perivascular Stem Cells for Bone Regeneration
07:05

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

Area of Science:

  • Orthopedic Surgery
  • Regenerative Medicine
  • Biomaterials Science

Context:

  • Vascularized pedicled bone grafts have been utilized since the early 20th century.
  • Microvascular bone grafts (free vascularized bone transfer) emerged in the 1970s.
  • Numerous studies have compared vascularized bone grafts to non-vascularized alternatives.

Purpose:

  • To evaluate the efficacy of vascularized bone grafts compared to non-vascularized grafts.
  • To highlight the advantages of vascularized bone grafts in fracture healing and bone defect repair.
  • To assess the outcomes of vascularized bone grafts in compromised recipient bed conditions.

Summary:

  • Vascularized bone grafts exhibit enhanced vitality due to an uninterrupted blood supply.
  • They demonstrate accelerated fracture healing, better adaptation to mechanical loads (e.g., hypertrophy), and higher survival rates.
  • These grafts are particularly effective in poor or compromised recipient beds, such as those with infection or poor vascularization, and possess neovascularization potential.

Impact:

  • Successful treatment of large segmental bone defects with minimal surgical interventions.
  • Reduced complication rates in treating complex combined soft tissue and bone defects.
  • Shifted indications for vascularized bone graft procedures due to their improved outcomes and versatility.