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Related Experiment Video

Updated: Jun 24, 2026

Fertility Preservation in Patients with Severe Ovarian Dysfunction

Fertility Preservation in Patients with Severe Ovarian Dysfunction

Published on: March 25, 2021

First Irish birth following IVF therapy using antagonist protocol.

E V Mocanu¹, N Kondaveeti, J Kelly

¹HARI Unit, Rotunda Hospital, Dublin 1, Ireland. emocanu@rcsi.ie

Irish Journal of Medical Science

|April 7, 2009

Summary

This case study details a successful in vitro fertilization (IVF) pregnancy using a gonadotropin-releasing hormone (GnRH) antagonist protocol. The patient delivered healthy twins, highlighting the efficacy of GnRH antagonist therapy in IVF.

Related Experiment Videos

Last Updated: Jun 24, 2026

Fertility Preservation in Patients with Severe Ovarian Dysfunction

Fertility Preservation in Patients with Severe Ovarian Dysfunction

Published on: March 25, 2021

Area of Science:

Reproductive Endocrinology
In Vitro Fertilization (IVF)

Background:

Traditional premature luteinizing hormone (LH) surge prevention in IVF used gonadotropin-releasing hormone agonists (GnRH-a).
GnRH antagonists offer a more recent alternative for LH surge suppression during controlled ovarian hyperstimulation.

Observation:

A 37-year-old woman with primary infertility underwent a second IVF cycle.
The patient had a 5-year history of infertility attributed to a frozen pelvis secondary to endometriosis.

Findings:

Controlled ovarian hyperstimulation, oocyte retrieval, fertilization, and embryo transfer were performed.
A successful pregnancy was established, resulting in a twin gestation diagnosed at 7 weeks.
The pregnancy concluded with the delivery of twin girls via emergency cesarean section.

Implications:

This represents the first reported delivery following IVF using a GnRH antagonist protocol in Ireland.
GnRH antagonist protocols are patient-friendly and suitable for wider clinical adoption.
This case supports the use of GnRH antagonists for successful IVF outcomes, even in complex infertility cases.