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Updated: Jun 24, 2026

Functional Cloning Using a Xenopus Oocyte Expression System

Functional Cloning Using a Xenopus Oocyte Expression System

Published on: January 30, 2016

Database of queryable gene expression patterns for Xenopus.

Michael J Gilchrist¹, Mikkel B Christensen, Odile Bronchain

¹Gurdon Institute, Cambridge University, Cambridge, United Kingdom. m.gilchrist@gurdon.cam.ac.uk

Developmental Dynamics : an Official Publication of the American Association of Anatomists

|April 7, 2009

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This summary is machine-generated.

This study introduces XenMARK, a new database for Xenopus gene expression patterns. It provides a searchable resource for understanding gene function during embryonic development.

Area of Science:

Developmental Biology
Genomics
Bioinformatics

Background:

Precise gene expression localization in developing embryos is crucial for understanding gene function.
Existing data on Xenopus gene expression patterns were largely inaccessible as a searchable resource.

Purpose of the Study:

To create a searchable database of Xenopus gene expression patterns.
To enable querying by specific embryonic locations or regions.
To facilitate the elucidation of gene function through accessible spatial and temporal expression data.

Main Methods:

Development of a novel, rapid manual annotation tool named XenMARK.
Utilizing in situ hybridization images and schematic diagrams of embryonic development stages.
Employing human cognitive abilities for pattern matching and data transfer to standardized geometry.

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Metabolic Labeling of the Nascent Transcriptome in Xenopus Early Embryogenesis

Metabolic Labeling of the Nascent Transcriptome in Xenopus Early Embryogenesis

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Functional Cloning Using a Xenopus Oocyte Expression System

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Genome-wide Snapshot of Chromatin Regulators and States in Xenopus Embryos by ChIP-Seq

Genome-wide Snapshot of Chromatin Regulators and States in Xenopus Embryos by ChIP-Seq

Published on: February 26, 2015

Metabolic Labeling of the Nascent Transcriptome in Xenopus Early Embryogenesis

Metabolic Labeling of the Nascent Transcriptome in Xenopus Early Embryogenesis

Published on: March 27, 2026

Main Results:

A new database of Xenopus gene expression patterns has been established.
The database allows pattern matching driven by existing images or user-defined schematic patterns.
Data was compiled from 21 researchers over 4 days using the XenMARK tool.

Conclusions:

The XenMARK database provides a valuable, searchable resource for the Xenopus research community.
This tool enhances the accessibility of gene expression data, aiding in the study of gene function.
The novel annotation method allows for efficient data capture and integration into a standardized format.