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Updated: Jun 24, 2026

Generation of Monoclonal Antibodies Against Natural Products
Published on: April 6, 2019
Anti-MRSA activity of aldehyde Schiff base N-aryl thiosemicarbazones
S Kriushnapriya1, N S Malathy, A Shamitha Begum
1PSG Institute of Medical Science & Research and PSG Hospitals, Coimbatore, Tamil Nadu, India. glory_kriush@yahoo.com
Abstract:
Eight different newly synthesised aldehyde Schiff base N-aryl thiosemicarbazones, differing in R, R' groups, are tested on 25 clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) and a standard strain. Antibacterial activity was carried out by a well-diffusion method in concentrations of 15-500 microg/well. Compounds 1, 2, 3, 4 and 6 showed good inhibition of MRSA. Increasing concentration of the test compounds enlarged the inhibition zone. Determination of minimum inhibitory concentration (MIC) was carried out using a dilution susceptibility test in concentrations of 4-512 microg/mL of the medium. The lowest MIC value (16 microg/mL) was produced by compound 4.
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