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Related Experiment Video

Updated: Jun 24, 2026

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors

Published on: June 7, 2016

[(Pro) renin receptor].

Atsuhiro Ichihara¹, Hiroshi Ito

¹Endocrinology and Anti-Aging Medicine, Department of Internal Medicine, Keio University School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine

|April 8, 2009

Summary

This summary is machine-generated.

The (pro)renin receptor is crucial in diabetes and hypertension, mediating angiotensin II-dependent and independent pathways. Assessing the renin to prorenin ratio is key to understanding its role in disease.

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Last Updated: Jun 24, 2026

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors

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Published on: June 27, 2015

Area of Science:

Endocrinology
Molecular Biology
Cardiovascular Research

Context:

The discovery of the (pro)renin receptor revealed prorenin's dual role as an inactive precursor and an endocrine hormone.
Prorenin binding to its receptor activates distinct intracellular signaling pathways.

Purpose:

To elucidate the role of the (pro)renin receptor in mediating end-organ damage in diabetes and hypertension.
To investigate the interplay between renin, prorenin, and the (pro)renin receptor in pathological conditions.

Summary:

The (pro)renin receptor initiates both angiotensin II-dependent (via nonproteolytic prorenin activation) and angiotensin II-independent pathways.
These receptor-mediated pathways significantly contribute to the progression of end-organ damage in diabetes and hypertension.
The receptor's contribution to pathogenesis is diminished in high-renin states, necessitating the evaluation of the renin-to-prorenin ratio.

Impact:

Highlights the (pro)renin receptor as a potential therapeutic target for managing diabetic and hypertensive complications.
Emphasizes the importance of assessing the renin-to-prorenin ratio for a comprehensive understanding of disease mechanisms.
Provides insights into the complex regulation of the renin-angiotensin system and its impact on organ damage.