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Updated: Jun 24, 2026

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Published on: April 27, 2016

[Vascular endothelial dysfunction].

Noriko Ide¹, Koichi Node

¹Department of Cardiovascular and Renal Medicine, Saga University Faculty of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine

|April 8, 2009

Summary

This summary is machine-generated.

Renin-angiotensin system (RAS) blockade, using ACE inhibitors or ARBs, can reverse endothelial dysfunction. This approach counteracts angiotensin II (AII)-induced damage, improving nitric oxide (NO) signaling and reducing oxidative stress for better vascular health.

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Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

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Published on: October 22, 2014

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Last Updated: Jun 24, 2026

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Published on: April 27, 2016

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

Area of Science:

Cardiovascular Biology
Endothelial Function
Vascular Medicine

Context:

Endothelial dysfunction is a key factor in atherosclerosis.
It involves an imbalance between vasodilators like nitric oxide (NO) and vasoconstrictors like angiotensin II (AII).
Angiotensin II (AII) in endothelial cells promotes reactive oxygen species (ROS) and impairs NO signaling.

Purpose:

To review recent findings on the beneficial effects of renin-angiotensin system (RAS) blockade on endothelial function.
To elucidate the mechanisms underlying RAS blockade's positive impact on endothelial cells.
To highlight RAS blockade as a therapeutic strategy against endothelial dysfunction.

Summary:

Endothelial cells regulate vascular tone, coagulation, growth, and inflammation.
Angiotensin II (AII), a product of the renin-angiotensin system (RAS), induces endothelial dysfunction by increasing ROS and inhibiting nitric oxide (NO) signaling.
RAS blockade, through ACE inhibitors and/or ARBs, offers a promising strategy to restore endothelial function.

Impact:

Provides insights into reversing endothelial dysfunction, a precursor to atherosclerosis.
Supports the therapeutic use of RAS inhibitors for cardiovascular health.
Enhances understanding of the molecular mechanisms linking RAS, oxidative stress, and NO bioavailability.