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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: Jun 24, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

[Skin tumours and primary multiple malignant neoplasms].

M I Kudrina, N N Vinogradova, N G Kolen'ko

    Klinicheskaia Meditsina
    |April 8, 2009
    PubMed
    Summary

    Recurrent skin cancer can lead to new cancers in other organs. This study tracked skin cancer patients, finding new malignancies in the skin, lungs, and other glands.

    Area of Science:

    • Oncology
    • Dermatology
    • Cancer Research

    Background:

    • Skin cancer, particularly basal cell carcinoma and squamous cell carcinoma, is a common malignancy.
    • Long-term follow-up is crucial for understanding the full spectrum of cancer recurrence and secondary malignancies.
    • Previous research indicates potential links between primary skin cancers and subsequent neoplasms in other organ systems.

    Purpose of the Study:

    • To analyze the structure and patterns of recurrent malignant neoplasms in patients previously treated for skin cancer.
    • To identify the incidence and common sites of secondary malignancies following primary skin cancer diagnosis.
    • To provide long-term data on cancer recurrence in a large cohort of skin cancer survivors.

    Main Methods:

    • A retrospective analysis of a cohort of 2801 patients.

    More Related Videos

    Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
    04:12

    Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)

    Published on: December 19, 2019

    Related Experiment Videos

    Last Updated: Jun 24, 2026

    A 3D Organotypic Melanoma Spheroid Skin Model
    08:49

    A 3D Organotypic Melanoma Spheroid Skin Model

    Published on: May 18, 2018

    Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
    04:12

    Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)

    Published on: December 19, 2019

  • Patients were diagnosed with primary basal cell carcinoma or squamous cell carcinoma.
  • Long-term follow-up was conducted over a 32-year period (1975-2006).

    • Main Results:

    • A total of 740 recurrent malignant neoplasms were identified.
    • The majority of recurrent neoplasms occurred in the skin.
    • Secondary malignancies were also frequently observed in the gastrointestinal tract, lungs, mammary glands, and prostate glands.

    Conclusions:

    • Patients with a history of skin cancer have an increased risk of developing recurrent skin malignancies.
    • There is a notable association between primary skin cancer and the development of secondary cancers in various organs.
    • Long-term surveillance is essential for early detection of recurrent and secondary neoplasms in skin cancer patients.