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Updated: Jun 24, 2026

Intravascular Delivery of Biologics to the Rat Kidney

Intravascular Delivery of Biologics to the Rat Kidney

Published on: September 1, 2016

[Renal changes in vasculitis: case report].

Kresimir Galesić¹, Jadranka Morović-Vergles, Danica Ljubanović

¹Odjel za nefrologiju, KB Dubrava, Interna klinika, 10000 Zagreb, Av. G. Suska 6. kresog@kbd.hr

Lijecnicki Vjesnik

|April 8, 2009

Summary

This study analyzed 15 patients with vasculitis affecting the kidneys. Most patients experienced significant renal insufficiency, with 9 achieving remission after treatment, while 5 required chronic dialysis.

Area of Science:

Nephrology
Rheumatology
Immunology

Context:

Vasculitis frequently involves renal manifestations, impacting kidney function.
Diagnosis and management of renal vasculitis present significant clinical challenges.
Understanding treatment outcomes is crucial for improving patient prognosis.

Purpose:

To analyze the clinical characteristics, renal biopsy findings, and treatment outcomes in patients with vasculitis and renal involvement.
To evaluate the efficacy of immunosuppressive therapy and supportive care in managing renal vasculitis.
To identify factors associated with remission and progression of renal failure in this patient cohort.

Summary:

Fifteen patients with vasculitis and renal manifestations were studied, with 13 undergoing renal biopsy.

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Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats

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Intravascular Delivery of Biologics to the Rat Kidney

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Published on: September 1, 2016

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats

Published on: March 11, 2016

Microscopic polyangiitis and Wegener's granulomatosis were common, often presenting with pauci-immune glomerulonephritis and crescents.

Most patients had baseline renal insufficiency; 9 achieved remission with immunosuppression and supportive care, while 5 progressed to chronic dialysis.

Impact:

The findings highlight the severity of renal involvement in vasculitis and the importance of timely immunosuppressive treatment.
Treatment with glucocorticosteroids and cyclophosphamide, sometimes combined with plasmapheresis, can lead to remission in a significant proportion of patients.
Despite treatment, a substantial number of patients develop end-stage renal disease requiring dialysis, underscoring the need for further therapeutic advancements.