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Surpassing the use of copper in the click functionalization of polymeric nanostructures: a strain-promoted approach
Enrique Lallana1, Eduardo Fernandez-Megia, Ricardo Riguera
1Departamento de Química Orgánica, Facultad de Química, and Unidad de RMN de Biomoléculas Asociada al CSIC, Universidad de Santiago de Compostela, AVda. de las Ciencias S.N., 15782 Santiago de Compostela, Spain.
Abstract:
The limitations (depolymerization and Cu contamination) in the use of Cu(I)-catalyzed azide-alkyne [3 + 2] cycloadditions (CuAAC) for the selective click functionalization of polysaccharide-based systems have been efficiently surpassed using a strain-promoted approach (SPAAC). The SPAAC decoration of chitosan-g-poly(ethylene glycol) nanostructures with an immunoglobulin G under physiological conditions represents a step forward in the preparation of immunonanoparticles.
