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Updated: Jun 24, 2026

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
Published on: March 14, 2025
Successful topical hemotherapy with a new occlusive dressing for an intractable ulcer on the toe
Michiko Iwayama-Hibino1, Kazumitsu Sugiura, Yoshinao Muro
1Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan. michikomichikomichiko@hotmail.com
Abstract:
Topical hemotherapy is a method of applying heparinized venous blood directly onto the surface of an ulcer, which is covered with an occlusive hydrocolloidal dressing. It is often effective on chronic ulcers with thick necrosis, because some proteinases and growth factors in plasma are probably involved in the digestion of necrotic tissues and the acceleration of granulation and epithelization. We treated a patient with an intractable ulcer on the toe caused by a peripheral circulatory disturbance due to her systemic sclerosis. As conventional topical hemotherapy cannot be applied to ulcers on the round tip of a toe, we made a device for occlusive dressing of topical hemotherapy which could successfully improve the previously refractory ulcer.
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