Related Experiment Video
Updated: Jun 22, 2026
07:43
Intracarotid Cancer Cell Injection to Produce Mouse Models of Brain Metastasis
Published on: February 8, 2017
Management of brain metastases
John H Suh1, Samuel T Chao, Michael A Vogelbaum
1Brain Tumor and Neuro-oncology Center, Department of Radiation Oncology, T28, 9500 Euclid Avenue, Cleveland, OH 44195, USA. suhj@ccf.org
Current Neurology and Neuroscience Reports
|April 8, 2009
Summary
Managing brain metastases involves balancing tumor control with neurocognitive function. This review examines radiation therapy, surgery, and other options for optimal patient outcomes.
Area of Science:
- Oncology
- Neurology
- Radiation Oncology
Background:
- Brain metastases are a frequent and severe complication of cancer.
- Treatment options have expanded due to advances in surgery, radiology, and oncology.
- Patient prognosis varies based on lesion number, extracranial disease, age, and functional status.
Purpose of the Study:
- To review current management strategies for brain metastases.
- To discuss the controversy surrounding whole brain radiation therapy's impact on neurocognitive function.
- To highlight the need for optimizing treatment to balance tumor control and functional status.
Main Methods:
- Review of literature on brain metastases management.
- Focus on whole brain radiation therapy, surgery, and stereotactic radiosurgery.
- Inclusion of radiation sensitizers and clinical trials.
Main Results:
- Increased treatment options for brain metastases.
- Concerns regarding neurocognitive impairment from whole brain radiation therapy.
- Controversial patient management with diverse opinions on optimal therapy.
Conclusions:
- Optimizing whole brain radiation therapy is crucial for best outcomes.
- Balancing tumor control and functional status is key in patient management.
- Further research and clinical trials are needed to refine treatment strategies.
