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Related Experiment Video

Updated: Jun 24, 2026

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

Published on: June 8, 2022

Percutaneous pulmonary valve implantation.

Philipp Lurz¹, Regis Gaudin, Andrew M Taylor

¹UCL Institute of Child Health and Great Ormond Street Hospital for Children, London, UK.

Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual

|April 8, 2009

Summary

Percutaneous pulmonary valve implantation offers a less invasive option for patients with dysfunctional conduits, reducing pressure and postponing surgery. While stent fractures occur, valve function remains good, with potential for wider application.

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Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels

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Published on: May 26, 2023

Area of Science:

Cardiology
Interventional Cardiology
Biomedical Engineering

Background:

Dysfunctional right ventricle to pulmonary artery conduits often necessitate repeat open-heart surgery.
Percutaneous pulmonary valve implantation (PPVI) presents a minimally invasive alternative.

Purpose of the Study:

To evaluate the efficacy and durability of PPVI in patients with dysfunctional conduits.
To assess the long-term outcomes and complications associated with PPVI.

Main Methods:

Retrospective analysis of patients undergoing PPVI for conduit dysfunction.
Assessment of hemodynamic parameters (right ventricular pressure, outflow tract gradient) and re-operation rates.
Monitoring for complications, including stent fractures and endocarditis.

Main Results:

Significant reductions in right ventricular pressure and outflow tract gradient were observed post-PPVI.
High rates of freedom from re-operation at various follow-up intervals (e.g., 93% at 10 months).
Stent fractures occurred in approximately 20% of cases, sometimes requiring valve-in-valve procedures; valvar function remained stable.

Conclusions:

PPVI is effective in managing dysfunctional pulmonary artery conduits, improving hemodynamics and delaying surgery.
Long-term durability is promising, though stent fractures represent a notable complication.
Further research is needed to expand PPVI to native outflow tracts and severe pulmonary regurgitation.