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Updated: Jun 24, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

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Episcleritis: an association with IgA nephropathy.

V Hegde¹, Izabela Mitrut, H Bennett

¹Princess Alexandra Eye Pavilion, Chalmers Street, Edinburgh EH3 9 HA, United Kingdom. vijayhegde@yahoo.com

Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association

|April 8, 2009

Summary

Recurrent episcleritis, an eye inflammation, can be an early sign of IgA nephropathy, a kidney disease. Basic urine tests are crucial for diagnosing this link.

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Area of Science:

Ophthalmology
Nephrology
Immunology

Background:

Immunoglobulin A (IgA) nephropathy is a common cause of glomerulonephritis.
Ocular manifestations of IgA nephropathy are rare and often overlooked.

Observation:

A 39-year-old male presented with recurrent episcleritis.
Initial investigations revealed microscopic hematuria and proteinuria.
Kidney biopsy confirmed IgA nephropathy.

Findings:

This case demonstrates a rare presentation of IgA nephropathy.
The ocular symptoms preceded overt signs of kidney disease.

Implications:

Highlights the importance of routine urinalysis in patients with unexplained inflammatory eye conditions.
Suggests considering IgA nephropathy in the differential diagnosis of recurrent episcleritis.
Emphasizes the utility of simple dipstick urinalysis for early detection.