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Mesenteric venous thrombosis due to protein C deficiency
P Yates1, P M Cumber, S Sanderson
1Department of Haematology, Bristol Royal Infirmary.
Clinical and Laboratory Haematology
|January 1, 1991
Insights
Protein C deficiency increases risk for blood clots. This report details two unusual cases of mesenteric venous thrombosis linked to protein C deficiency, highlighting less common presentations.
Area of Science:
- Medical Science
- Hematology
- Vascular Medicine
Background:
- Protein C deficiency is an established risk factor for thromboembolic events.
- Common clinical manifestations include thrombophlebitis, deep venous thrombosis, and pulmonary embolism.
Observation:
- Two cases of mesenteric venous thrombosis (MVT) were identified.
- Both patients were diagnosed with protein C deficiency.
Findings:
- Mesenteric venous thrombosis is a less common, yet recognized, presentation of protein C deficiency.
- Increased availability of protein C assays aids in diagnosing rarer clinical scenarios.
Implications:
- Highlights the importance of considering protein C deficiency in patients with MVT.
- Suggests broader screening for protein C deficiency in unexplained thrombotic events.
- Contributes to understanding the diverse clinical spectrum of protein C deficiency.
Abstract:
Protein C deficiency is a known underlying risk factor for thromboembolic disease. Most commonly it presents as thrombophlebitis, deep venous thrombosis or pulmonary embolism. Less common presentations are becoming increasingly recognized now that assays for protein C are more widely available. We present two cases of mesenteric venous thrombosis who were found to have protein C deficiency.