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Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells
Published on: February 15, 2019
Nonhuman primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246
John Huggins1, Arthur Goff, Lisa Hensley
1U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
Abstract:
ST-246, a potent orthopoxvirus egress inhibitor, is safe and effective at preventing disease and death in studies of small-animal models involving challenge by several different pathogenic poxviruses. In this report, the antiviral efficacy of ST-246 in treatment of nonhuman primates infected with variola virus or monkeypox virus was assessed. The data indicate that oral dosing once per day with ST-246 protects animals from poxvirus disease, as measured by reductions in viral load and numbers of lesions and enhancement of survival.
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