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Related Experiment Video

Updated: Jun 24, 2026

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
07:03

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Published on: July 31, 2019

Brain atrophy in primary lateral sclerosis.

M C Tartaglia1, V Laluz, A Rowe

  • 1Department of Clinical Neurological Sciences, London Health Sciences Centre, London, Ontario, Canada.

Neurology
|April 8, 2009
PubMed
Summary
This summary is machine-generated.

Primary lateral sclerosis (PLS) patients show reduced brain volumes, particularly in the precentral cortex and corpus callosum. These findings suggest focal atrophy in PLS, impacting motor pathways.

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Area of Science:

  • Neuroscience
  • Neurology
  • Radiology

Background:

  • Primary lateral sclerosis (PLS) is a rare, idiopathic degenerative disorder affecting upper motor neurons.
  • Understanding the neuroanatomical changes in PLS is crucial for diagnosis and management.

Purpose of the Study:

  • To compare brain volumes between patients with PLS and healthy controls.
  • To investigate whether observed brain volume differences are attributable to gray matter (GM), white matter (WM), or both.

Main Methods:

  • T1-weighted MRI scans were acquired from 11 PLS patients and 10 controls.
  • Volumetric analysis using Freesurfer segmented brain regions including whole brain, cortical GM, specific cortical areas (precentral, postcentral), WM, corpus callosum, basal ganglia, thalamus, cerebellum, and CSF.
  • Correlations were examined between disease severity, disease duration, age, and brain volumes.

Main Results:

  • PLS patients exhibited significantly smaller whole brain, frontal lobe, precentral cortex, and corpus callosum volumes compared to controls.
  • A trend towards smaller thalamus volume was observed in PLS patients.
  • Disease severity correlated with increased ventricular CSF volume and precentral cortex volume loss. Disease duration showed a trend correlating with WM loss.

Conclusions:

  • Focal brain atrophy is present in PLS patients, notably in the precentral cortex and corpus callosum.
  • These atrophic changes are particularly significant in areas involved in the transfer of motor fibers.
  • The study highlights specific neuroanatomical regions affected in PLS, contributing to understanding its pathophysiology.