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Updated: Jun 24, 2026
08:51
Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry
Published on: March 1, 2013
Bioreducible polymers for efficient gene and siRNA delivery
Dhananjay Jere1, Rohidas Arote, Hu-Lin Jiang
1Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Korea.
Biomedical Materials (Bristol, England)
|April 8, 2009
Summary
Bioreducible polymers with disulfide linkages show promise for delivering genes and siRNA. This review covers recent advances, advantages, and challenges of these reducible polymeric carriers in drug delivery.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery Systems
Background:
- Disulfide linkage-based drug conjugates are approved for drug delivery.
- These systems demonstrate significant potential for gene and small interfering RNA (siRNA) transfection.
- Polymeric carriers offer versatile platforms for advanced therapeutic delivery.
Purpose of the Study:
- To review recent developments in bioreducible polymeric systems for gene and siRNA delivery.
- To discuss the advantages of using reducible polymeric carriers.
- To highlight the challenges associated with these advanced delivery systems.
Main Methods:
- Literature review of recent advancements in bioreducible polymeric systems.
- Analysis of studies focusing on gene and siRNA delivery applications.
- Evaluation of the advantages and challenges of reducible polymeric carriers.
Main Results:
- Bioreducible polymers offer enhanced payload release and improved cellular uptake.
- Disulfide bond cleavage in response to intracellular reducing environments facilitates efficient delivery.
- Various polymeric architectures are being explored for optimized transfection efficiency.
Conclusions:
- Reducible polymeric carriers represent a promising strategy for efficient gene and siRNA delivery.
- Further research is needed to overcome challenges related to stability, immunogenicity, and large-scale production.
- These advanced materials hold potential for next-generation nucleic acid-based therapeutics.
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