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TB vaccines: current status and future perspectives

Claus Aagaard1, Jes Dietrich, Mark Doherty

  • 1Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark.

Immunology and Cell Biology
|April 8, 2009
PubMed

Vaccines against intracellular pathogens such as Mycobacterium tuberculosis need to induce strong cellular immune responses. Antigen discovery programs have exploited this and used proteome studies and T-cell recognition in PPD-positive individuals to select proteins and after testing for protective efficacy in animals the most promising proteins have been put together in fusion molecules. Three such fusion proteins are currently in clinical trials, the two most advanced have already passed phase I trials and are entering phase II.

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