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Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome

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[Cardiovascular aging].

Raúl J Domenech¹, Pilar Macho

¹Instituto de Ciencias Biomédicas, Universidad de Chile, Santiago, Chile. rdomenec@med.uchile.cl

Revista Medica De Chile

|April 8, 2009

Summary

This summary is machine-generated.

Cardiovascular aging involves arterial and heart remodeling, increasing cardiovascular disease risk. While exercise helps, no specific treatments prevent age-related decline, though new drugs are under investigation.

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Assessment of Vascular Function in Patients With Chronic Kidney Disease

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Area of Science:

Cardiovascular physiology
Aging research
Vascular biology

Context:

Cardiovascular changes occur throughout life, beginning in adolescence.
These changes accelerate with age, becoming a significant risk factor for cardiovascular diseases.
Arterial stiffening and left ventricular remodeling are key age-related cardiovascular alterations.

Purpose:

To describe the physiological changes in the cardiovascular system associated with aging.
To identify the mechanisms underlying age-related cardiovascular dysfunction.
To review current and potential therapeutic strategies for cardiovascular aging.

Summary:

Aging causes progressive arterial remodeling, increasing pulse wave velocity and aortic impedance.
Left ventricular remodeling leads to diastolic and systolic dysfunction, reducing exercise capacity.
Oxidative stress and mitochondrial mutations further decrease aerobic capacity, while microvascular damage affects organs like the brain and kidneys.
Research is ongoing to identify genetic factors and develop treatments, including novel drugs targeting aortic molecular structure.

Impact:

Understanding cardiovascular aging is crucial for developing targeted interventions.
Identifying genetic markers could enable early risk assessment.
Future therapies may mitigate age-related cardiovascular decline and improve quality of life in older adults.