[BIS-monitoring of sedative therapy of children in intensive care units]

Area of Science:

• Pediatric intensive care medicine
• Anesthesiology
• Pharmacology

Background:

• Assessing sedation depth is critical in pediatric intensive care units (PICUs) for managing critically ill children.
• Severe purulent abdominal processes and somatic diseases often require deep sedation for effective treatment and patient comfort.

Purpose of the Study:

• To investigate and compare the depth of sedation achieved in pediatric patients with severe abdominal conditions.
• To evaluate the efficacy of different sedative agents, specifically relanium and midazolam, in achieving target sedation levels.

Main Methods:

• A study involving 65 children aged 4-14 years with severe purulent abdominal processes and somatic diseases.
• Sedation depth was monitored using Bispectral Index (BIS) monitoring and assessed clinically via the Ramsey sedation scale.
• Comparative analysis of sedation depth following administration of relanium and midazolam.

Main Results:

• Significant differences in sedation depth were observed between the groups receiving different sedative agents.
• The study found a clear correlation between the administered dose of sedative agents and the resulting depth of sedation.
• BIS monitoring and Ramsey scale provided complementary data on sedation levels.

Conclusions:

• Sedation depth in pediatric patients with severe abdominal conditions is dose-dependent for both relanium and midazolam.
• Both BIS monitoring and the Ramsey scale are valuable tools for assessing sedation depth in this population.
• Tailoring sedative agent dosage is crucial for optimizing sedation management in PICU settings.