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Photoregulated release of caged anticancer drugs from gold nanoparticles
Sarit S Agasti1, Apiwat Chompoosor, Chang-Cheng You
1Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA.
Journal of the American Chemical Society
|April 9, 2009
Abstract:
An anticancer drug (5-fluorouracil) was conjugated to the surface of gold nanoparticles through a photocleavable o-nitrobenzyl linkage. In this system, the particle serves as both cage and carrier for the therapeutic, providing a nontoxic conjugate that effectively releases the payload upon long wavelength UV irradiation.
