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Related Experiment Video

Updated: Jun 24, 2026

High-resolution Optical Mapping of the Mouse Sino-atrial Node
11:07

High-resolution Optical Mapping of the Mouse Sino-atrial Node

Published on: December 2, 2016

Mouse models for studying pacemaker channel function and sinus node arrhythmia.

Andreas Ludwig1, Stefan Herrmann, Evelyn Hoesl

  • 1Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Fahrstrasse 17, D-91054 Erlangen, Germany. ludwig@pharmakologie.uni-erlangen.de <ludwig@pharmakologie.uni-erlangen.de>

Progress in Biophysics and Molecular Biology
|April 9, 2009
PubMed
Summary
This summary is machine-generated.

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The heart's pacemaker activity relies on sinoatrial node (SAN) cells and the I(f) current generated by hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. Genetic mouse models reveal the role of I(f) in normal pacemaking and arrhythmias.

Area of Science:

  • Cardiology
  • Molecular Biology
  • Electrophysiology

Background:

  • The sinoatrial node (SAN) generates the heart's pacemaker activity through spontaneously active cells.
  • The precise molecular mechanisms of SAN pacemaker potentials are not fully understood.
  • Hyperpolarization-activated cation channels (HCN) and the I(f) current are implicated in spontaneous electrical activity.

Purpose of the Study:

  • To review recent findings on the role of cardiac HCN channel subtypes in pacemaking.
  • To discuss the contribution of I(f) to normal pacemaking and sinus node arrhythmias using genetic models.
  • To introduce a new mouse model for temporally-controlled gene targeting in SAN cells.

Main Methods:

  • Analysis of transgenic mice lacking specific cardiac HCN channel subtypes.

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Last Updated: Jun 24, 2026

High-resolution Optical Mapping of the Mouse Sino-atrial Node
11:07

High-resolution Optical Mapping of the Mouse Sino-atrial Node

Published on: December 2, 2016

Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice
09:20

Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice

Published on: July 5, 2021

Programmed Electrical Stimulation in Mice
07:29

Programmed Electrical Stimulation in Mice

Published on: May 26, 2010

  • Investigation of the I(f) current's role in pacemaking and arrhythmias.
  • Description of a novel mouse line enabling selective, temporally-controlled gene targeting in SAN cells.

    • Main Results:

    • Transgenic mouse models have provided insights into the function of HCN channels in cardiac pacemaking.
    • The I(f) current plays a significant role in both normal SAN function and sinus node arrhythmias.
    • A new genetic tool allows for precise manipulation of gene expression in SAN cells.

    Conclusions:

    • Elucidating HCN channel function in well-controlled mouse models is crucial for understanding SAN function.
    • Further research using these models will enhance our understanding of human sinoatrial arrhythmias.
    • Targeted gene manipulation in SAN cells offers a powerful approach to study cardiac electrophysiology.