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Related Experiment Video

Updated: Jun 24, 2026

CRISPR-Cas9-Mediated Precise Knock-In Edits in Zebrafish Hearts
06:52

CRISPR-Cas9-Mediated Precise Knock-In Edits in Zebrafish Hearts

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Zebrafish genetic models for arrhythmia.

David J Milan1, Calum A Macrae

  • 1Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Progress in Biophysics and Molecular Biology
|April 9, 2009
PubMed
Summary
This summary is machine-generated.

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The zebrafish is a valuable genetic model organism for studying vertebrate organogenesis, cardiac electrophysiology, and disease. Its transparent embryos and genomic resources offer unique advantages for in vivo research and drug discovery.

Area of Science:

  • Developmental Biology and Genetics
  • Cardiovascular Physiology
  • Pharmacology and Toxicology

Background:

  • The zebrafish has become a prominent genetic model organism over the past decade.
  • Its utility stems from transparent embryos ideal for studying vertebrate organogenesis.
  • Advancements in genetic screens, genome sequencing, and genomic resources have solidified its role.

Purpose of the Study:

  • To review the zebrafish's growing potential in in vivo cell biology, physiology, disease modeling, and drug discovery.
  • To highlight research in cardiac electrophysiology, developmental physiology, and large-scale screens.
  • To emphasize the zebrafish's complementary role to other research models and its future potential.

Main Methods:

  • Review of existing literature on zebrafish research.

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Last Updated: Jun 24, 2026

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Published on: September 13, 2022

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Published on: August 16, 2024

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  • Focus on cardiac electrophysiology and developmental physiology.
  • Analysis of large-scale genetic screens and high-throughput disease modeling.

    • Main Results:

    • The zebrafish offers unique advantages for in vivo studies due to its genetic tractability and transparent embryos.
    • It serves as a valuable model for understanding cardiac electrophysiology and developmental processes.
    • Its application in disease modeling and drug discovery is rapidly expanding.

    Conclusions:

    • The zebrafish is a powerful and versatile model organism with significant potential in various biological and biomedical research areas.
    • Its strengths lie in its suitability for in vivo cell biology, physiological studies, and high-throughput screening.
    • Continued research will further unlock the zebrafish's capabilities in disease modeling and therapeutic development.