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Methods to Identify the NMR Resonances of the 13C-Dimethyl N-terminal Amine on Reductively Methylated Proteins
13:59

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Published on: December 12, 2013

Reduced amino acid alphabets exhibit an improved sensitivity and selectivity in fold assignment

Eric L Peterson1, Jané Kondev, Julie A Theriot

  • 1Department of Physics, California Institute of Technology, Pasadena, CA 91125, USA.

Bioinformatics (Oxford, England)
|April 9, 2009
PubMed
Summary

Using reduced amino acid alphabets can improve protein fold recognition. These simplified alphabets, grouping similar amino acids, often outperform full alphabets in sequence alignment and detecting structurally similar proteins with low sequence identity.

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