Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tegafur-induced acral hyperpigmentation.

E Llistosella1, A Codina, R Alvarez

  • 1Department of Dermatology, Hospital de Girona, Spain.

Cutis
|September 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Simplified risk-prediction for benchmarking and quality improvement in emergency general surgery. Prospective, multicenter, observational cohort study.

International journal of surgery (London, England)·2021
Same author

Nasopharyngeal carcinoma: 30-year experience of a single institution in a non-endemic area.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2017
Same author

Oral cavity, pharynx and larynx nodules.

European annals of otorhinolaryngology, head and neck diseases·2016
Same author

Anti-VDRL antibodies by ELISA in cerebrospinal fluid and its value in the differential diagnosis of abnormalities of the cerebrospinal fluid.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015
Same author

Impact of a multidisciplinary team training programme on rectal cancer outcomes in Spain.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2013
Same author

[Dermatological uncertainties].

Actas dermo-sifiliograficas·2010
Same journal

Black Dots on the Scalp of a Child.

Cutis·2026
Same journal

Psoriasis and Obesity: A Clinical Review of the Bidirectional Link and Management Implications.

Cutis·2026
Same journal

Adalimumab in Lichen Planus: A Narrative Review of Treatment and Paradoxical Reactions.

Cutis·2026
Same journal

The Future of Psoriasis Care.

Cutis·2026
Same journal

Evaluating GPT-4o for Automated Classification of Skin Lesions Using the HAM10000 Dataset.

Cutis·2026
Same journal

Metastatic Primary Extramammary Paget Disease: A Case Series.

Cutis·2026
See all related articles

Tegafur, a colorectal cancer drug, caused unusual skin hyperpigmentation on palms, soles, nails, and the glans penis in four patients. This previously unreported side effect resolved after discontinuing the cytotoxic medication.

Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Colorectal cancer treatment often involves cytotoxic chemotherapy.
  • Fluoropyrimidines, such as 5-fluorouracil and its analogues like tegafur, are common chemotherapeutic agents.
  • Adverse drug reactions can significantly impact patient quality of life and treatment adherence.

Purpose of the Study:

  • To report a novel mucocutaneous side effect associated with tegafur treatment.
  • To describe the clinical and histopathologic features of this unique hyperpigmentation.
  • To raise awareness among clinicians regarding this potential adverse event.

Main Methods:

  • Observation of four colorectal cancer patients undergoing tegafur therapy.
  • Clinical documentation of hyperpigmentation on palms, soles, nails, and glans penis.

Related Experiment Videos

  • Histopathologic examination of affected skin tissue.

    • Main Results:

    • Patients developed macular, spotted hyperpigmentation localized to specific mucocutaneous areas.
    • Histopathology revealed epidermal basal hyperpigmentation with a lentiginous pattern.
    • Lesions resolved spontaneously within two months of treatment cessation.

    Conclusions:

    • Tegafur may cause a distinct pattern of hyperpigmentation as a previously unreported side effect.
    • The observed phenomenon highlights the importance of recognizing unusual dermatologic manifestations of chemotherapy.
    • Spontaneous resolution suggests a reversible mechanism related to drug exposure.