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Tegafur-induced acral hyperpigmentation
E Llistosella1, A Codina, R Alvarez
1Department of Dermatology, Hospital de Girona, Spain.
Cutis
|September 1, 1991
Abstract:
Four patients with colorectal cancer treated with tegafur (a fluoropyrimidine structurally similar to 5-fluorouracil) noted a macular, spotted hyperpigmentation limited to the palms, soles, nails, and glans penis. Histopathologic examination disclosed epidermal basal hyperpigmentation with a lentiginous pattern. Mucocutaneous lesions resolved spontaneously two months after treatment was discontinued. This peculiar phenomenon seems to represent a previously unreported side effect of this cytotoxic drug.