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Related Concept Videos

Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
G-Protein Gated Ion Channels01:21

G-Protein Gated Ion Channels

GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory organs,...
Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for their...
Ligand-gated Ion Channels01:19

Ligand-gated Ion Channels

Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that include the...
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein01:20

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
GPCRs Regulate Adenylyl Cylase Activity01:09

GPCRs Regulate Adenylyl Cylase Activity

Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of cells.
Two...

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Related Experiment Video

Updated: Jun 24, 2026

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors
07:51

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors

Published on: November 14, 2014

KChIP1: a potential modulator to GABAergic system.

Hui Xiong1, Kun Xia, Benshang Li

  • 1School of Life Sciences, Fudan University, Shanghai 200433, China.

Acta Biochimica Et Biophysica Sinica
|April 9, 2009
PubMed
Summary
This summary is machine-generated.

Kv channel interacting protein 1 (KChIP1) modulates neuronal A-type current and is crucial for the GABAergic inhibitory system. KChIP1 deficiency in mice increases seizure susceptibility, highlighting its role in neuronal function.

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Last Updated: Jun 24, 2026

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors
07:51

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Published on: November 14, 2014

Whole-cell Currents Induced by Puff Application of GABA in Brain Slices
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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Ion Channel Physiology

Background:

  • Kv channel interacting proteins (KChIPs) are known modulators of Kv4 (Shal) channels, impacting cardiac and neuronal currents.
  • Four KChIP family members (KChIP1-4) have been identified, with KChIP1 showing predominant expression in the brain.

Purpose of the Study:

  • To investigate the role of KChIP1 in the central nervous system.
  • To determine the functional significance of KChIP1 in neuronal activity and its relationship with the GABAergic system.

Main Methods:

  • In situ hybridization and immunostaining assays to determine KChIP1 expression patterns in the brain.
  • Analysis of KChIP1-deficient mice to assess its role in brain development and seizure susceptibility.
  • Functional studies using transgenic mice, immunoprecipitation, gene expression analysis, and heterologous expression.

Main Results:

  • KChIP1 is expressed in a subpopulation of parvalbumin-positive neurons, suggesting a link to GABAergic inhibitory neurons.
  • KChIP1 deficiency did not affect survival or overall brain architecture, indicating no essential role in brain development.
  • KChIP1-deficient mice exhibited increased susceptibility to pentylenetetrazole-induced seizures, pointing to a role in the GABAergic system.

Conclusions:

  • KChIP1 plays a significant role in the GABAergic inhibitory system.
  • KChIP1 is not essential for brain development but is critical for regulating neuronal excitability and preventing seizures.