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Related Experiment Video

Updated: Jun 24, 2026

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

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Published on: January 20, 2019

Azurophilic inclusions in plasma cells.

N Ali¹, B Moiz

¹Department of Pathology & Microbiology, Section of Haematology, The Aga Khan University Hospital, PO Box 3500, Stadium Road, Karachi 74800, Pakistan. natasha.ali@aku.edu

Singapore Medical Journal

|April 9, 2009

Summary

A rare bone marrow finding of plasmacytosis with unusual inclusions was observed in a patient with chest pain. These morphological features, while rare, do not appear to impact prognosis.

Area of Science:

Hematology
Oncology
Pathology

Background:

Bone marrow examination is crucial for diagnosing hematological malignancies.
Plasmacytosis, an increase in plasma cells, can indicate various conditions, including multiple myeloma.

Observation:

A 45-year-old male presented with chest pain and weight loss.
Bone marrow aspirate revealed 95% plasmacytosis.

Findings:

Plasma cells contained coarse, Auer rod-like azurophilic inclusions.
These inclusions were negative for Sudan Black B and periodic acid Schiff stains.
Such inclusions are rarely reported and primarily of morphological significance.

Implications:

This case highlights a rare morphological finding in plasma cells.

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The presence of these inclusions may warrant careful morphological review but lacks established prognostic value.

Further research into the nature and origin of these inclusions could enhance diagnostic criteria.