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Published on: February 12, 2017
Severe respiratory symptoms to oxaliplatin infusion: a case report of delayed hypersensitivity reaction
Simona Potenza1, Guglielmo Nasti, Alessandro Ottaiano
1Department of Experimental Medicine, Section of Pharmacology L. Donatelli, Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy. simipot@hotmail.it
Abstract:
A 46-year-old man with adenocarcinoma of the sigmoid colon developed a hypersensitivity reaction after the sixth cycle of combination chemotherapy with oxaliplatin infusion. Hypersensitivity to oxaliplatin occurring, after several courses of therapy, in about 10-15% of patients, especially during or immediately after the oxaliplatin infusion. In this case report we present a delayed hypersensitivity reaction, consisting in dysesthesia and laryngeal spasm developed 10 h after the sixth administration of oxaliplatin.
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