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Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

Rheumatic Heart Disease I: Introduction

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...

Chronic Bowel Disorders: Introduction

Chronic Bowel Disorders: Introduction

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Cirrhosis I: Introduction

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Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...

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Related Experiment Video

Updated: Jun 24, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

[Scleroderma and fibrosing diseases].

U A Walker¹, P Knöss, M Jakobs

¹Rheumatologische Universitätsklinik, Universität Basel, Burgfelderstrasse 101, Basel, Switzerland. ulrich.walker@fps-basel.ch

Zeitschrift Fur Rheumatologie

|April 9, 2009

Summary

Fibroblasts drive fibrotic diseases like systemic sclerosis and fibromatoses, often involving inflammation. Histopathology is key for diagnosing these fibroblast-driven conditions.

Area of Science:

Cell Biology
Pathology

Context:

Fibroblasts and myofibroblasts are central to the pathogenesis of various fibrotic diseases.
Conditions discussed include systemic sclerosis, fibromatoses, arthrofibrosis, and Ormond's disease.
These diseases involve excessive fibroblast proliferation and inflammation.

Purpose:

To elucidate the role of fibroblasts and myofibroblasts in fibrotic diseases.
To highlight the diagnostic significance of histopathology in fibrosing conditions.

Summary:

Fibrotic diseases such as systemic sclerosis, fibromatoses, arthrofibrosis, and Ormond's disease are characterized by fibroblast and myofibroblast proliferation, often with inflammation.
Scleroderma presents as localized or systemic with vasculopathy, and similar skin lesions can occur in graft-versus-host disease, malignancy, or drug reactions.

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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

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Published on: June 16, 2020

Chronic Salmonella Infection Induced Intestinal Fibrosis

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Fibromatoses range from superficial to deep desmoids, while Ormond's disease is a retroperitoneal periaortitis.

Impact:

Histopathological diagnosis provides crucial, ranging from supportive to definitive, value in identifying fibrosing diseases.
Understanding fibroblast roles aids in diagnosing and potentially treating these conditions.