Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Voluntary hyperventilation in obesity hypoventilation.

J Leech1, E Onal, R Aronson

  • 1Department of Medicine, Ottawa Civic Hospital, Ontario, Canada.

Chest
|November 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Incidentally identified aortic dissection in a Great Pyrenees dog.

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2025
Same author

Evaluating the effectiveness of a vancomycin stewardship programme in a level IV neonatal intensive care unit.

The Journal of hospital infection·2025
Same author

Prospective analysis of whole blood utilisation and implications for blood distribution.

BMJ military health·2024
Same author

Canadian Real-World Outcomes of Omnipod Initiation in People with Type 1 Diabetes (COPPER study): Evidence from the LMC Diabetes Registry.

Diabetic medicine : a journal of the British Diabetic Association·2020
Same author

The C-Band All-Sky Survey (C-BASS): Simulated parametric fitting in single pixels in total intensity and polarization.

Monthly notices of the Royal Astronomical Society·2019
Same author

SGLT2 inhibitors and incretin agents: Associations with alanine aminotransferase activity in type 2 diabetes.

Diabetes & metabolism·2018
Same journal

A Comparative Study of Radiation Exposure in Conventional and Robotic Bronchoscopy.

Chest·2026
Same journal

Independent Prognostic Contributions of Anti-Ro52 and Anti-MDA5 in Autoimmune-Associated Interstitial Lung Disease.

Chest·2026
Same journal

Lung aeration and gas exchange in SGA or AGA infants with moderate-severe BPD: secondary analysis of the PATH-BPD study.

Chest·2026
Same journal

Lung Cancer Incidence and Mortality after Negative Low-Dose CT Screening Results.

Chest·2026
Same journal

Symptom prevalence and impact on lung cancer risk in the SUMMIT study.

Chest·2026
Same journal

How I Do It: De-escalation of Prostacyclin-Based Therapy in Patients Treated With Sotatercept.

Chest·2026
See all related articles

Patients with obstructive sleep apnea (OSA) and daytime hypercapnia can usually normalize CO2 levels through voluntary hyperventilation, suggesting impaired ventilatory control is key. Respiratory mechanics may also contribute, especially in obesity hypoventilation.

Area of Science:

  • Pulmonary Medicine
  • Sleep Medicine
  • Respiratory Physiology

Background:

  • Obstructive sleep apnea (OSA) is frequently associated with daytime hypercapnia.
  • The underlying mechanisms contributing to hypercapnia in OSA are not fully elucidated.
  • Voluntary hyperventilation is a tool to assess ventilatory control and respiratory mechanics.

Purpose of the Study:

  • To investigate the role of ventilatory control and respiratory mechanics in maintaining daytime hypercapnia in patients with OSA.
  • To examine the relationship between the fall in PaCO2 after hyperventilation and patient characteristics.

Main Methods:

  • Arterial blood gas analysis was performed before and after voluntary hyperventilation (60-90 seconds) in 27 patients with OSA and daytime hypercapnia.
  • PaCO2 changes were correlated with age, BMI, sleep-disordered breathing indices, and pulmonary function tests (spirometry).

Related Experiment Videos

Main Results:

  • Most patients could normalize PaCO2 with voluntary hyperventilation, indicating preserved ventilatory responsiveness.
  • Subjects with airflow obstruction had more difficulty normalizing PaCO2.
  • The percentage fall in PaCO2 correlated significantly with FEV1/FVC ratio and FEV1.
  • Post-hyperventilation PaCO2 correlated with FEV1, unlike baseline PaCO2.

Conclusions:

  • Impaired ventilatory control appears to be the primary driver of hypercapnia in OSA.
  • Respiratory mechanical impairment, particularly in those with airflow obstruction, may play a secondary role in hypercapnia, especially in obesity hypoventilation.