Chiral recognition of hybrid metal oxide by peptides
Kévin Micoine1, Bernold Hasenknopf, Serge Thorimbert
1UPMC Univ Paris 06, Institut Parisien de Chimie Moléculaire (UMR CNRS 7201), C. 229, 4 place Jussieu, 75005 Paris, France.
Angewandte Chemie (International Ed. in English)
|April 9, 2009
Abstract:
Resolution of gram quantities of a subtly chiral polyoxometalate (POM; the chirality originates from substitution of one metal in the nanosized framework) is possible by reaction with small peptides. Functionalizable acyl polyoxotungstate (TBA)(6)[alpha(1)-P(2)W(17)O(61){SnCH(2)CH(2)C(=O)}] (see picture) can be resolved by kinetic resolution. This approach paves the way for applications of chiral POMs ranging from asymmetric catalysis to their bioactivity.
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