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Stem cells improve left ventricular function in acute myocardial infarction.

Sarabjeet Singh1, Rohit Arora, Kamna Handa

  • 1Department of Medicine, Division Cardiology, Chicago Medical School, Chicago, Illinois 60660, USA. sarabjeetsingh_2000@yahoo.com

Clinical Cardiology
|April 9, 2009
PubMed
Summary

Intracoronary bone marrow stem cell (BMC) therapy shows promise for improving cardiac function after acute myocardial infarction. This meta-analysis found a significant increase in left ventricular ejection fraction (LVEF) in patients receiving BMC treatment compared to controls.

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Area of Science:

  • Cardiology
  • Regenerative Medicine
  • Clinical Trials

Background:

  • Animal studies suggest bone marrow cells (BMC) improve cardiac function post-myocardial infarction via regeneration or neovascularization.
  • Clinical studies have yielded mixed results, necessitating further investigation.
  • The efficacy of intracoronary stem cell therapy for acute myocardial infarction (AMI) remains uncertain.

Purpose of the Study:

  • To investigate the effectiveness of intracoronary stem cell therapy in improving cardiac function after AMI.
  • To analyze data from existing randomized controlled trials through a meta-analysis.

Main Methods:

  • Systematic literature search identified 7 randomized controlled trials.
  • Meta-analysis included 516 patients (256 BMC group, 260 control).

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Last Updated: Jun 24, 2026

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  • Primary endpoint: change in global left ventricular ejection fraction (LVEF) from baseline to 3-6 month follow-up.

    • Main Results:

    • No significant baseline differences between BMC treatment and control groups.
    • BMC group showed a significantly greater increase in LVEF compared to the control group (mean difference: 6.108%, P<.001).

    Conclusions:

    • Intracoronary bone marrow stem cell infusion appears effective for improving left ventricular systolic function in post-AMI patients.
    • Findings support BMC therapy as a potential treatment to enhance cardiac function recovery after acute myocardial infarction.