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Serum oxidative stress level correlates with clinical parameters in chronic systolic heart failure patients

Offer Amir1, Hagar Paz, Ori Rogowski

  • 1Department of Cardiology, Lady Davis Carmel Medical Center, Haifa, Israel. ruthiea@wincol.ac.il

Clinical Cardiology
|April 9, 2009
PubMed

Insights

High serum oxidative stress (OS) levels in chronic heart failure patients correlate with advanced disease. This finding highlights OS as a potential prognostic marker in heart failure management.

Area of Science:

  • Cardiology
  • Biochemistry
  • Internal Medicine

Background:

  • Oxidative stress (OS) plays a significant role in the inflammatory processes associated with heart failure (HF).
  • Understanding OS markers is crucial for managing chronic HF.

Purpose of the Study:

  • To analyze serum OS levels in patients with chronic heart failure (HF).
  • To investigate the relationship between OS levels and clinical/prognostic parameters in HF patients.

Main Methods:

  • Studied 82 chronic symptomatic HF patients with systolic left ventricular (LV) dysfunction (ejection fraction <45%).
  • Serum OS levels were quantified using a thermochemiluminescence assay.
  • OS levels were compared against clinical and prognostic patient parameters.

Main Results:

  • Elevated serum OS levels were linked to higher New York Heart Association (NYHA) class.
  • Higher OS correlated with poorer renal function, including serum urea, creatinine, and creatinine clearance.
  • Increased OS was associated with elevated levels of hs-C-reactive protein and N-terminal pro brain natriuretic peptide.

Conclusions:

  • In patients with chronic systolic HF, elevated serum OS levels are associated with more advanced disease.
  • High OS levels correlate with established markers of poor prognosis in heart failure.
Abstract

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