Radiation-induced osteosarcoma with a rhabdomyosarcoma component arising from the dura mater: a case report
1Department of Neurosurgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan. utsuki@med.kitasato-u.ac.jp
Objective:
Radiation-induced tumors are a rare complication of radiation therapy. Here, we describe the first case of a radiation-induced osteosarcoma with a rhabdomyosarcoma component arising from the dura mater after radiation therapy for an astrocytoma.
Patient:
An 18-year-old man with generalized seizures presented with a neoplastic lesion in the dura mater of a previously irradiated (56 Gy) region 5 years after the initial radiation therapy. A tumor resection was performed, and histological examination revealed an osteosarcoma with a rhabdomyosarcoma component. The tumor recurred despite eight tumorectomies and the addition of chemotherapy and radiotherapy. The patient died from tumor progression 5 years after the first surgical removal of the radiation-induced tumor.
Conclusion:
This radiation-induced tumor may have originated from primitive, multipotent mesenchymal cells, as it included both osteosarcoma and rhabdomyosarcoma components.
