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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

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Minimal Erythema Dose (MED) Testing
06:24

Minimal Erythema Dose (MED) Testing

Published on: May 28, 2013

Immunologically mediated photodermatoses: diagnosis and treatment.

Thilo Gambichler1, Raida Al-Muhammadi, Stefanie Boms

  • 1Department of Dermatology, Ruhr-University Bochum, Bochum, Germany. t.gambichler@klinikum-bochum.de

American Journal of Clinical Dermatology
|April 10, 2009
PubMed
Summary

Immunologically mediated photodermatoses (IMP) are diverse skin conditions triggered by UV light, causing significant discomfort and reduced quality of life. Diagnosis and treatment involve photodiagnostics, photoprotection, and sometimes immunosuppressive therapies.

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Area of Science:

  • Dermatology
  • Immunology
  • Photobiology

Background:

  • Electromagnetic radiation, particularly UVA, can induce specific skin conditions.
  • Immunologically mediated photodermatoses (IMP) are a group of disorders with pathological skin reactions to optical radiation.
  • The precise mechanisms of IMP are not fully understood but are likely autoimmune.

Purpose of the Study:

  • To review the heterogeneous group of immunologically mediated photodermatoses (IMP).
  • To highlight the impact of IMP on patients' quality of life.
  • To discuss diagnostic and therapeutic strategies for IMP.

Main Methods:

  • Literature review of IMP, including polymorphic light eruption, actinic prurigo, hydroa vacciniforme, chronic actinic dermatitis, and solar urticaria.
  • Discussion of photodiagnostic procedures for determining action spectra and photosensitivity.
  • Overview of photoprotection, photo(chemo)therapy, and immunomodulatory treatments.

Main Results:

  • IMP encompass several distinct conditions, including polymorphic light eruption and solar urticaria.
  • Symptoms like intractable itch and pain significantly impair quality of life.
  • Photodiagnostics are crucial for accurate diagnosis and management.

Conclusions:

  • IMP represent a significant group of disabling skin conditions.
  • Effective management requires broad-spectrum photoprotection and potentially advanced therapies.
  • Further research into the pathomechanisms of IMP is warranted.