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Updated: Aug 6, 2026

Procedures for In Vitro Cultivation of Treponema pallidum, the Syphilis Spirochete
Published on: January 24, 2025
Primary syphilis of the rectum--endoscopic and clinical features. Report of a case
1Digestive Endoscopy Unit, Ospedale Nuovo Regina Margherita, Rome, Italy.
Abstract:
A 33-year-old man was admitted to our hospital for suspected rectal tumor. Endoscopy showed a rectal mass not typical of carcinoma, and histologic evaluation of biopsy specimens revealed granulomatous inflammation. Venereal Disease Research Laboratories (VDRL) and Treponema pallidum hemagglutination (TPHA) tests became positive during hospitalization, and dark-field examination was positive for Treponemas, thus allowing the diagnosis of chancre of the rectum. The clinical and endoscopic features of this case are described.
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