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10:26
Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology
Published on: August 18, 2014
Fesoterodine: a new agent for treating overactive bladder.
Pamela Ellsworth1, Sandra J Berriman, Marina Brodsky
1Brown University, 122 Shaw Ave, Cranston, RI 02905-3833, USA. pamelaellsworth@aol.com
The American Journal of Managed Care
|April 10, 2009
Summary
Fesoterodine effectively treats overactive bladder (OAB) symptoms, reducing urgency and incontinence. Clinical trials show fesoterodine is well-tolerated and safe for OAB patients.
Area of Science:
- Pharmacology
- Urology
Background:
- Overactive bladder (OAB) is a chronic condition impacting both genders.
- Key symptoms include urinary urgency, with or without incontinence, frequency, and nocturia.
Purpose of the Study:
- To evaluate the efficacy and safety of fesoterodine, a novel antimuscarinic agent.
- Focus on fesoterodine's role in managing overactive bladder symptoms.
Main Methods:
- Systematic review of pivotal Phase 3 clinical trials for fesoterodine in OAB treatment.
- Analysis focused on efficacy and safety data relevant to US prescribing information.
Main Results:
- Once-daily administration of fesoterodine (4 mg and 8 mg) demonstrated significant improvement over placebo in OAB symptoms.
- Improvements were measured using changes in bladder diary variables.
- Both fesoterodine dosages were found to be well-tolerated in study participants.
Conclusions:
- Fesoterodine is an effective treatment option for individuals suffering from overactive bladder.
- The drug is well-tolerated, indicating a favorable safety profile for OAB management.
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