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Related Concept Videos

Lipid Catabolism01:25

Lipid Catabolism

Triglycerides serve as crucial long-term energy storage molecules in microorganisms, providing a dense source of metabolic energy. Their breakdown is mediated by lipases, which hydrolyze triglycerides into glycerol and free fatty acids. Each of these components follows distinct metabolic pathways, ultimately contributing to ATP synthesis and cellular energy homeostasis.Glycerol MetabolismGlycerol, released from triglyceride hydrolysis, is phosphorylated by glycerol kinase to form...
Fats as Energy Storage Molecules01:06

Fats as Energy Storage Molecules

Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis directly...
Fats as Energy Storage Molecules01:06

Fats as Energy Storage Molecules

Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis directly...
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Overview of Fatty Acid Metabolism01:28

Overview of Fatty Acid Metabolism

Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
Lipid Absorption01:24

Lipid Absorption

Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...

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Related Experiment Video

Updated: Jun 24, 2026

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro
09:41

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro

Published on: March 17, 2023

Triacylglycerol metabolism.

Haralabos C Karantonis1, Tzortzis Nomikos, Constantinos A Demopoulos

  • 1Department of Science of Nutrition-Dietetics, Harokopio University, Athens, Greece.

Current Drug Targets
|April 10, 2009
PubMed
Summary

Triacylglycerols are key energy stores and regulators of fatty acid metabolism. Recent discoveries in triacylglycerol metabolism offer insights into diseases linked to lipid imbalances.

Area of Science:

  • Biochemistry
  • Metabolic Regulation
  • Lipid Metabolism

Background:

  • Triacylglycerols (TAGs) are the primary energy reserves in the human body.
  • TAG metabolism influences fatty acid oxidation, plasma free fatty acid levels, lipid biosynthesis, and lipoprotein fate.
  • Regulatory mechanisms (allosteric, hormonal, nutritional, transcriptional) control TAG storage and mobilization.

Purpose of the Study:

  • To summarize recent advancements in understanding triacylglycerol metabolism.
  • To highlight newly discovered enzymes and regulatory mechanisms.
  • To elucidate the biochemical basis of diseases involving triacylglycerols.

Main Methods:

  • Review of recent scientific literature on triacylglycerol metabolism.
  • Analysis of newly identified enzymes and regulatory pathways.

More Related Videos

A Fluorescence-based Assay for Characterization and Quantification of Lipid Droplet Formation in Human Intestinal Organoids
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A Fluorescence-based Assay for Characterization and Quantification of Lipid Droplet Formation in Human Intestinal Organoids

Published on: October 13, 2019

Related Experiment Videos

Last Updated: Jun 24, 2026

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro
09:41

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro

Published on: March 17, 2023

A Fluorescence-based Assay for Characterization and Quantification of Lipid Droplet Formation in Human Intestinal Organoids
10:12

A Fluorescence-based Assay for Characterization and Quantification of Lipid Droplet Formation in Human Intestinal Organoids

Published on: October 13, 2019

  • Integration of current knowledge on lipid biochemistry and metabolic regulation.

    • Main Results:

    • Identification of novel enzymes and regulatory mechanisms in TAG metabolism.
    • Elucidation of fine-tuning in metabolic reactions governing TAGs.
    • Enhanced understanding of TAG's role in various metabolic processes.

    Conclusions:

    • Recent discoveries are refining our comprehension of TAG metabolism.
    • This knowledge is crucial for understanding the biochemical underpinnings of diseases related to triacylglycerols.
    • Further research into TAG metabolism will aid in disease pathogenesis insights.