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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
11:14

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Published on: November 10, 2013

Copper compounds in anticancer strategies.

Saverio Tardito1, Luciano Marchiò

  • 1Centre de Recherche du CHUL, Centre de Endocrinologie et Génomique, Université Laval, 2705 boul Laurier, Québec, G1V 4G2, QC, Canada.

Current Medicinal Chemistry
|April 10, 2009
PubMed
Summary
This summary is machine-generated.

Copper's chemical properties are vital for biological functions. Exploiting cancer cells' need for copper offers a novel anticancer strategy by inducing toxic metal accumulation.

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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
07:20

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

Related Experiment Videos

Last Updated: Jun 24, 2026

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
11:14

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Published on: November 10, 2013

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
07:20

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

Area of Science:

  • Biochemistry and Molecular Biology
  • Metallomics
  • Cancer Biology

Background:

  • Copper is an essential trace element involved in critical biological processes like electron transfer and catalysis.
  • Organisms have evolved sophisticated copper-handling mechanisms due to its potential toxicity.
  • Copper complexes are investigated for anticancer properties, primarily through oxidative stress induction and proteasome inhibition.

Purpose of the Study:

  • To explore the multifaceted roles of copper in biological systems.
  • To review the anticancer potential of copper complexes, including their mechanisms of action.
  • To discuss novel therapeutic strategies targeting tumor copper metabolism.

Main Methods:

  • Review of existing literature on copper biochemistry and its role in cancer.
  • Analysis of studies on copper complexes' in vitro and in vivo anticancer activities.
  • Evaluation of therapeutic approaches involving copper modulation in cancer treatment.

Main Results:

  • Copper's redox activity (+1/+2 states) is crucial for biological functions.
  • Copper complexes induce cancer cell death via oxidative stress, proteasome inhibition, and apoptosis.
  • Emerging evidence suggests copper compounds can trigger non-apoptotic programmed cell death.
  • Copper is essential for angiogenesis, presenting a target for anti-tumor therapies.

Conclusions:

  • Copper's dual role as an essential element and a potential toxin provides unique therapeutic opportunities.
  • Targeting tumor-specific copper accumulation represents a promising new avenue for cancer treatment.
  • Further research into copper-based therapies could lead to innovative anticancer strategies.