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Apoptosis and oxidative stress-related diseases: the p66Shc connection

Michela Pellegrini1, Cosima T Baldari

  • 1Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy. pellegrini.m@unisi.it

Current Molecular Medicine
|April 10, 2009
PubMed

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Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
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