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Published on: May 13, 2022
Modelling and measuring redox cycling and cytotoxicity of quinones
Louise Hughes1, Jordana Wingate, Renate Griffith
1School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia.
Abstract:
The roles of alkylation and redox cycling in quinone toxicity were investigated. In general the more cytotoxic quinones produced the highest responses in an assay monitoring redox activity. No evidence of alkylation of high molecular weight protein thiols was detected. We conclude quinone toxicity is dominated by redox cycling.
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