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Updated: Jun 24, 2026
Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats
Published on: December 14, 2014
Early malnutrition favours heavy ethanol intake in weaning rats without long-lasting effects
A S Aguiar1, R F Abrahão, T L Freitas
1Núcleo de Ciéncias Comportamentais e do Desenvolvimento, Departamento de Fisiologia e Farmacologia, Instituto Biomédico, Universidade Federal Fluminense, Rio de Janeiro, Brasil.
Introduction:
Although food restriction is well known to increase ethanol intake, the subject has not been extensively studied in developing animals which could be more vulnerable to long-lasting effects. Therefore, the aim of this study was to show some findings concerning this subject.
Materials And Methods:
Food restriction was used to produce malnutrition either during lactation (lactating dams food restricted 60%) or after weaning (pups food restricted 60%). At weaning, day 25, males were assigned to one of the following groups: C, food ad libitum throughout the experiment - control group; MW, malnourished only after weaning; ML, malnourished only during lactation period; and MLW, malnourished throughout the experiment, during lactation and after weaning. All rats were kept isolated in cages in which they could choose to drink either a 10% ethanol solution or tap water (from days 25 to 45). Re-exposure to this model was performed on day 49. Between exposure and re-exposure, rats drank tap water for 4 days.
Results:
There was a significant effect of malnutrition during lactation, up to day 35, with heavy drinking patterns (ethanol intake day 2: C, 8 g/kg; MW, 9 g/kg; ML, 19 g/kg; and MLW, 22 g/kg). This heavy drinking pattern lasted until the recovery of body weight. Food restriction after weaning had significant effects after 14 days, when a statistically significant decrease in body weight occurred (body weight day 39: C, 147.8 g; MW, 98.5 g). Only rats which were persistently malnourished (MLW and MW) drank ethanol more significantly than their ad libitum-fed counterparts during the re-exposure period (ethanol intake: malnourished, 5 g/kg; and well-nourished, 2.5 g/kg). Adulteration of the ethanol solution with quinine (0.1 g/l) precluded the effect of malnutrition.
Conclusions:
Malnutrition during early development had no long-lasting effects on ethanol consumption. In addition, malnutrition increased ethanol consumption as long as it kept body weight low, which was apparently more significant in young animals.
